Cochrane has raised concerns about delays in time to wound healing when SSD is used. Other reviews of the evidence have also concluded, " quality of the trials was limited". Another Cochrane systematic review from 2010 concluded, "There is insufficient evidence to establish whether silver-containing dressings or topical agents promote wound healing or prevent wound infection". A Cochrane review from 2013 found that most of the trials that met inclusion criteria for the review had methodological shortcomings and thus are of little use in assessing the efficacy of silver sulfadiazine in the healing of burn injuries. Tentative evidence has found other antibiotics to be more effective in the healing of superficial and partial thickness burn injuries therefore, it is no longer generally recommended. It is on the World Health Organization's List of Essential Medicines. Silver sulfadiazine was discovered in the 1960s. It is not recommended for use in children less than two months of age. It should not be used in pregnant women who are close to delivery. Caution should be used in those allergic to other sulfonamides. Other side effects include low white blood cell levels, allergic reactions, bluish grey discoloration of the skin, red blood cell breakdown, or liver inflammation. Ĭommon side effects include itching and pain at the site of use. Tentative evidence has found other antibiotics to be more effective, and therefore it is no longer generally recommended for second-degree (partial-thickness) burns, but is still widely used to protect third-degree (full-thickness) burns. These signs include pain, increasing redness or pus where this medicine is being used.Silver sulfadiazine, sold under the brand Silvadene among others, is a topical antibiotic used in partial thickness and full thickness burns to prevent infection. Seek medical attention if you see any signs of a serious infection. Do not take 2 doses of this medicine at one time.ĭo not share this medicine with anyone who has not been prescribed this medicine. If it is almost time for the next dose, do not take the missed dose. If you forget to take a dose on time, take it as soon as you remember. It is important that you keep taking each dose of this medicine on time even if you are feeling well. Tell the doctor or pharmacist if you are pregnant, planning to be pregnant, or breastfeeding. Symptoms of an allergic reaction can include trouble breathing, skin rash, itching, swelling, or severe dizziness.ĭo not use the medication any more than instructed.Ĭontact your doctor if you notice a change in the amount or darkening of your urine. Tell your doctor and pharmacist if you ever had an allergic reaction to a medicine. Also tell them about any vitamins, herbal medicines, or anything else you take for your health. Include both prescription and over-the-counter medicines. Please tell your doctor and pharmacist about all the medicines you take. You may reapply the medicine during the day if the wound becomes dirty and needs to cleaned. If medicine gets in your eyes, rinse well with warm water. Wash your hands after using this medicine unless your hands are part of the area being treated.ĭo not touch your eyes, nose or mouth after handling the medicine. Wash your hands before and after handling this medicine. Use sunscreen lotion with SPF 15 or higher. Wash the medicine off your fingers after applying it.Īvoid prolonged or excessive sunlight exposure. This medicine should only be used on the skin.ĭo not apply other lotions, creams or gels to the same place you apply this medicine.Īvoid getting the medicine in the eyes, nose, or mouth. If some of the medicine rubs off, reapply it right away to make sure the wound is covered. Use fabric tape to hold the gauze in place.Īpply a thin layer to completely cover the wound. Use sterile gloves or a sterile applicator to apply the medicine.Īpply medicine directly to wound or onto a sterile gauze pad that is then applied to the wound. Wash the area first before applying medicine.
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